A peptide interaction in the major groove of RNA resembles protein interactions in the minor groove of DNA.
نویسندگان
چکیده
منابع مشابه
A peptide interaction in the major groove of RNA resembles protein interactions in the minor groove of DNA.
A 17-amino acid arginine-rich peptide from the bovine immunodeficiency virus Tat protein has been shown to bind with high affinity and specificity to bovine immunodeficiency virus transactivation response element (TAR) RNA, making contacts in the RNA major groove near a bulge. We show that, as in other peptide-RNA complexes, arginine and threonine side chains make important contributions to bin...
متن کاملthe major groove of RNA resembles protein interactions in the minor groove ofDNA
A 17-amino acid arginine-rich peptide from the bovine immunodeficiency virus Tat protein has been shown to bind with high affinity and specificity to bovine immunodeficiency virus transactivation response element (TAR) RNA, making contacts in the RNA major groove near a bulge. We show that, as in other peptide-RNA complexes, arginine and threonine side chains make important contributions to bin...
متن کاملProtein and drug interactions in the minor groove of DNA.
Interactions between proteins, drugs, water and B-DNA minor groove have been analyzed in crystal structures of 60 protein-DNA and 14 drug-DNA complexes. It was found that only purine N3, pyrimidine O2, guanine N2 and deoxyribose O4' are involved in the interactions, and that contacts to N3 and O2 are most frequent and more polar than contacts to O4'. Many protein contacts are mediated by water,...
متن کاملFluorescent d(CGCGAATTCGCG): characterization of major groove polarity and study of minor groove interactions through a major groove semantophore conjugate
The major and minor groove in duplex DNA are sites of specific molecular recognition by DNA-binding agents such as proteins, drugs and metal complexes and have functional significance. In view of this, understanding of the inherent differences in their environment and the allosteric information transfer between them induced by DNA-binding agents assumes importance. Site-specific incorporation o...
متن کاملProtein–RNA interactions: Getting into the major groove
RNA–protein interactions are involved in many cellular processes, including information storage and transfer, catalysis and transcriptional activation. Our structural knowledge of these interactions at atomic resolution is based on X-ray crystallographic and nuclear magnetic resonance (NMR) studies (for a review see [1]). The crystal structures of a number of RNA–protein complexes have been rep...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 1995
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.92.11.5077